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Risk factors for cardiovascular disease in patients with periodontitis

Identifieur interne : 007E58 ( Main/Exploration ); précédent : 007E57; suivant : 007E59

Risk factors for cardiovascular disease in patients with periodontitis

Auteurs : Ka Re Buhlin [Suède] ; Anders Gustafsson [Suède] ; A. Graham Pockley [Royaume-Uni] ; Johan Frostega Rd [Suède] ; Bjo Rn Klinge [Suède]

Source :

European Heart Journal [ 0195-668X ] ; 2003-12-01.

RBID : ISTEX:67731720594C5ADB245A07D533AB41841E7A64B2

Descripteurs français

Wicri :
- topic : Maladie cardio-vasculaire.

English descriptors

Abstract

Aims This study compared plasma levels of established risk markers for atherosclerosis and indices of inflammation in 50 patients with severe periodontitis to those in 46 healthy cases. Methods and results Full blood counts were performed and levels of high density lipoproteins (HDL), total cholesterol, haptoglobin, elastase, C-reactive protein (CRP), IL-6, TNFα receptor-1, α-1-antitrypsin and antibodies against human heat shock protein (Hsp) 60, mycobacterial Hsp65 and oxLDL were determined. Total cholesterol levels were similar in both groups, whereas HDL levels were lower (P=0.007) and the lipid profile (total cholesterol/HDL) was consequentially higher (P=0.03) in patients. Monocyte counts were elevated (0.56 vs 0.44×109/l; P=0.002) and CRP levels were higher in patients, but TNFα receptor-1 and elastase levels were not. Anti-oxLDL antibody levels were similar, as were levels of haptoglobin, IgG anti HSP60, IgA and IgG anti-Hsp65 antibodies. Levels of IgA anti-Hsp60 antibodies were lower in patients (P=0.0001). Logistic regression analysis revealed a relationship between periodontitis and HDL (OR 2.15/0.5mmol/l, P=0.02) and body mass index (OR 4.54 P=0.005) Conclusion Serological differences in subjects with periodontitis, some of which involve established risk factors for atherosclerosis, might provide insight into the reported epidemiological association between periodontitis and cardiovascular disease.

Url:

https://api.istex.fr/document/67731720594C5ADB245A07D533AB41841E7A64B2/fulltext/pdf

DOI: 10.1016/j.ehj.2003.09.016

Affiliations:

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Le document en format XML

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<term>Buhlin</term>
<term>Cardiovascular</term>
<term>Cardiovascular disease</term>
<term>Cardiovascular diseases</term>
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<term>Clinical signs</term>
<term>Comparison group</term>
<term>Comparison groups</term>
<term>Coronary heart disease</term>
<term>Dental plaque</term>
<term>Epidemiological association</term>
<term>European society</term>
<term>Exercise test</term>
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<term>Gingival</term>
<term>Gingival inflammation</term>
<term>Gingival margin</term>
<term>Gingival pockets</term>
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<term>Healthy smokers</term>
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<term>Lipoprotein</term>
<term>Medical care</term>
<term>Monocyte counts</term>
<term>Neutrophil activation</term>
<term>Odds ratios</term>
<term>Oral bacteria</term>
<term>Patient group</term>
<term>Patients smokers</term>
<term>Periodontal</term>
<term>Periodontal disease</term>
<term>Periodontitis</term>
<term>Periodontitis patients</term>
<term>Periodontitisa patients</term>
<term>Periodontol</term>
<term>Peripheral blood</term>
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<term>Significant correlations</term>
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<term>Subgroup analyses</term>
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<term>Blood pressure</term>
<term>Body mass index</term>
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<term>Cardiovascular</term>
<term>Cardiovascular disease</term>
<term>Cardiovascular diseases</term>
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<term>Clin physiol</term>
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<term>Clinical signs</term>
<term>Comparison group</term>
<term>Comparison groups</term>
<term>Coronary heart disease</term>
<term>Dental plaque</term>
<term>Epidemiological association</term>
<term>European society</term>
<term>Exercise test</term>
<term>Gender</term>
<term>Gingival</term>
<term>Gingival inflammation</term>
<term>Gingival margin</term>
<term>Gingival pockets</term>
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<term>Healthy smokers</term>
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<term>Karolinska institutet</term>
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<term>Monocyte counts</term>
<term>Neutrophil activation</term>
<term>Odds ratios</term>
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<term>Patients smokers</term>
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<term>Periodontitisa patients</term>
<term>Periodontol</term>
<term>Peripheral blood</term>
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<term>Subgroup</term>
<term>Subgroup analyses</term>
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<front><div type="abstract" xml:lang="en">Aims This study compared plasma levels of established risk markers for atherosclerosis and indices of inflammation in 50 patients with severe periodontitis to those in 46 healthy cases. Methods and results Full blood counts were performed and levels of high density lipoproteins (HDL), total cholesterol, haptoglobin, elastase, C-reactive protein (CRP), IL-6, TNFα receptor-1, α-1-antitrypsin and antibodies against human heat shock protein (Hsp) 60, mycobacterial Hsp65 and oxLDL were determined. Total cholesterol levels were similar in both groups, whereas HDL levels were lower (P=0.007) and the lipid profile (total cholesterol/HDL) was consequentially higher (P=0.03) in patients. Monocyte counts were elevated (0.56 vs 0.44×109/l; P=0.002) and CRP levels were higher in patients, but TNFα receptor-1 and elastase levels were not. Anti-oxLDL antibody levels were similar, as were levels of haptoglobin, IgG anti HSP60, IgA and IgG anti-Hsp65 antibodies. Levels of IgA anti-Hsp60 antibodies were lower in patients (P=0.0001). Logistic regression analysis revealed a relationship between periodontitis and HDL (OR 2.15/0.5mmol/l, P=0.02) and body mass index (OR 4.54 P=0.005) Conclusion Serological differences in subjects with periodontitis, some of which involve established risk factors for atherosclerosis, might provide insight into the reported epidemiological association between periodontitis and cardiovascular disease.</div>
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Risk factors for cardiovascular disease in patients with periodontitis

Risk factors for cardiovascular disease in patients with periodontitis

Source :

Descripteurs français

English descriptors

Abstract

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